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Creatine levels in people with heart failure also reduce significantly, leading some researchers to suggest that creatine supplementation may support improved function

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This requires that the lens be transparent, a condition dependent on the highly regular organization of the cells of the lens and the high degree of short-range order of the proteins in the lens cytoplasm

A more recent in vitro study (2025) found that Akkermansia cell extracts induced a significant dose-dependent increase in GLP-1 secretion from human L-cells

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