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Current suicidal thoughts and/or prior suicidal attempt 6

This mechanism distinguishes it from semaglutide, which primarily targets GLP-1, and tirzepatide, which targets GLP-1 and GIP

Treatment should be discontinued after 12 weeks if patients have not lost at least 5% of their initial body weight

That means counting precise calories or macros rather than just, say, following a Mediterranean diet

Emerging clinical evidence, such as the STEP-HFpEF and FLOW trials, underscores the efficacy of GLP-1RAs in alleviating symptoms, improving quality of life, and slowing disease progression in HFpEF patients

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