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Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43Reference Yuksel, Yuksel and Yagmurca45)

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Ideally, if safe, statin rechallenge should be attempted to further prove causation

L-Carnitine aids in the transfer of fats to the mitochondria, where they are burned for energy, which helps to promote weight loss

doi: 10.1016/j.peptides.2007.03.015