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Hypothyroidism (underactive thyroid) is a common cause of cold intolerance in the general population and should be excluded if symptoms are persistent (NHS)

61 Mahul-MellierA.-L.BurtscherJ.MaharjanN.WeerensL.CroisierM.KuttlerF.et al (2020)

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Modifications in intestinal microbial structure compromise barrier integrity, facilitating bacterial product migration into the portal circulation

Wrap the gel pack in a thin cloth or paper towel to prevent direct contact with the vial, which could cause freezing