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Peternel , Bele M, Gaberc-Porekar V, Menart V
Higher doses do not guarantee faster results
To more fully characterize the quality of evidence supporting recommendations, the Practice Guidelines Committee of the AASLD requires a Class (reflecting benefit versus risk) and Level (assessing strength or certainty) of Evidence to be assigned and reported with each recommendation (Table 1, adapted from the American College of Cardiology and the American Heart association Practice Guidelines)
Then, the MR-Egger regression intercept assessed horizontal pleiotropy, indicating pleiotropy when deviating from zero (27)