Romidepsin: A new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors
J Orthop Trauma
These and many other early experiments that used viscometry to study protein denaturation and unfolding laid the groundwork for understanding intrinsically disordered states by showing that a rigid, compact, globular protein has a small effect on viscosity because it occupies a small hydrodynamic volume (they typically have a low intrinsic viscosity, in the range of 34 mL/g, which is independent of protein molecular mass), whereas an unfolded, flexible, or disordered protein adopts a random coil-like conformation, creating a much larger hydrodynamic volume that increases the solutions viscosity (intrinsic viscosity of unfolded proteins increases with increase in molecular mass)
The influenza virus also possesses hemagglutinin glycoprotein on its surface, which helps the virus in binding to cells rich in sialic acids like erythrocytes
Interestingly, the expression of these genes increases with tumor staging of NSCLC (Supplementary Fig
Liposomes may aggregate, leak their contents or undergo phospholipid oxidation if the formulation and packaging are inadequate
