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These changes can be categorized broadly into global/repetitive element methylation, gene-specific methylation, miRNA methylation, epigenetic clock genes alterations (see above), and methylation of immune- and retroviral-related elements 204

Altered ligand binding and transcriptional regulation by mutations in the PML/RAR ligand-binding domain arising in retinoic-acid-resistant patients with acute promyelocytic leukemia

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