While GLP-1 receptor agonists, like semaglutide (found in medications such as Wegovy and Ozempic), are associated with weight loss, individual responses can vary greatly
Introduce these gradually over 12 weeks to allow your digestive system to adjust without triggering excessive gas
As with any bioactive compound, physician supervision is important
Patient monitoring should include: Baseline lipid panel, hemoglobin A1c, and liver function tests Blood pressure monitoring (GLP-1 agents typically reduce systolic BP by 3-5 mmHg) [10] Assessment for gastrointestinal adverse effects during dose titration Evaluation for contraindications (personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2) [1] [3] Monitoring for gallbladder disease (increased risk with rapid weight loss) In patients with diabetes and retinopathy, monitoring for worsening eye symptoms, particularly with rapid glycemic improvement Renal function assessment, especially if severe gastrointestinal symptoms cause dehydration Patients should seek immediate medical attention for severe abdominal pain, which may indicate pancreatitisa rare but serious adverse effect
2017;11:CD012037
This may help explain why GLP-1 drugs are so effective in helping some people with obesity lose weight
