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2.2 Synovium and infrapatellar fat pad In OA, the synovial membrane exhibits marked pathological remodeling characterized by lining layer hyperplasia, sublining fibrosis, increased vascularization, and infiltration of immune cells, particularly macrophages, lymphocytes, and mast cells

In our batch-handling workflow, pre-measured delivery has two practical consequences for reproducibility: dose-to-dose variance is constrained by the device mechanism rather than by pipetting technique, and inter-operator drift across a multi-week study window is meaningfully reduced

Manuscript Writing and Revision: CB, JR, JOS, and NL-L