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In this study, the results of flow cytometry, immunofluorescence staining, RT-qPCR and ELISA assays demonstrated that GLP-1RAs could drive macrophage polarization towards the M2 type, thereby inhibiting the continuous development of synovitis

Despite this, the direction of effect was consistent across all four trials, with no evidence of increased risk in any individual study, supporting the coherence of the observed clinical signal

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