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48 children (ages ~312) were randomized to leucovorin (2 mg/kg per day, max 50 mg, split twice daily) or placebo

The ROS generated through radiolysis of cellular water and the free iron take part in the Fenton reaction-mediated lipid peroxidation of the plasma membrane and finally cell death through ferroptosis (Fig

Genomic Regulation: It resets the gene expression of the Ubiquitin-Proteasome System (UPS), enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes)

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Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

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