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However, the journey from understanding the basic mechanisms to the application of these insights in clinical settings involves overcoming several challenges, including optimizing drug efficacy, minimizing side effects, and ensuring long-term safety and tolerability

Gout flares and mortality after sodium-glucose cotransporter-2 inhibitor treatment for gout and type 2 diabetes

Nat Microbiol 6:10431054

Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]

Temporary protecting groups help prevent unwanted reactions, while deprotection steps expose the next reactive site for coupling