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database analysis of 461,382 adults on GLP-1 medications revealed the following deficiency progression[2]Nutritional Deficiencies in GLP-1 Users NCBI View source: The comparison against other diabetes medications is especially stark: These numbers reflect a consistent pharmacodynamic pattern.[12]Vitamin D and Peripheral Neuropathy Muscle Nerve View source The risk is highest in the first year of treatment and compounds over time without proactive supplementation.[11]Vitamin D Status and B12 Interaction J Nutr Sci View source Clinical Consequences of Vitamin D Depletion During Weight Loss Vitamin D deficiency during rapid weight loss is not a minor inconvenience it has compounding clinical consequences that can undermine the benefits of GLP-1 therapy[3]Vitamin D Deficiency Mayo Clinic View source: Accelerated bone loss vitamin D is required for calcium absorption.[13]Vitamin D Deficiency and Neurological Manifestations Nutrients View source Without it, your body pulls calcium from bone to maintain serum levels, increasing fracture risk during the very period you are losing weight rapidly see our article on vitamin D and osteoporosis prevention Muscle weakness and fatigue vitamin D receptors are present in muscle tissue
It's not a matter of 'if,' but 'when' and 'how fast.' And what you reconstitute it with is arguably the most important decision you'll make
Looking at this, initially there was a key case control study that came out in twenty twenty four, in the journal nature that looked at depression, anxiety and suicidal behavior in patients taking GLP-1 for weight management
doi: 10.1152/ajprenal.00280.2019 26 ItoM.TanakaT.NangakuM
After a week, Spencer said, her blood pressure dropped so low she thought she might pass out, so she stopped taking hypertension medicine
