It took the brand manufacturers more than two years to build enough capacity for the FDA to declare the shortages over, which happened on December 19, 2024, for Eli Lillys tirzepatide products, and February 21, 2025, for Novo Nordisks semaglutide products
The clinical implications of this are profound
DOI: 10.1080/19390211.2016.1203856
Your doctor can help you transition to appropriate diabetes or weight management strategies that are safe during pregnancy planning and can ensure your contraceptive method is appropriate during this transition period
Pharmacodynamics and pharmacokinetics From a pharmacodynamics perspective, pseudoephedrine presents a sympathomimetic action both directly, by exerting agonist activity on 1 , 2 and 1 adrenergic receptors, and indirectly, by inducing the release of norepinephrine from sympathetic neuron terminals, enhancing the effects of catecholamines [55]
This phenomenon has been observed with intensive glucose control even before [the] popularization of GLP-1 medications. It is likely more about how quickly glucose improves than about a harmful drug effect, he added