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Furthermore, ferulic acid treatment in a mouse model of neuroinhibition reduces p-JNK, p-NFB in glial cells of the mouse hippocampus and activates mitochondrial apoptotic molecules (Bax, cytochrome c, caspase-3, and PARP-1) in small/medium glial cells to induce anti-inflammatory effects by interfering with the TLR4/MD2 complex binding site (Nagarajan et al., 2015)

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Acta 208:538540