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& McCall, C

pylori ) is a Gram-negative, microaerophilic spiral bacterium, characterized by its unique morphology and flagella, which enable it to traverse the mucus layer in the acidic gastric environment and adhere to epithelial cells, thereby triggering local inflammatory responses

Studies on GSTO1-1 also suggested a protective effect of this enzyme on PD, exerted through the inhibition of the active form of interleukin-1 (IL-1 ) which is a critical factor in inflammatory response 47,58

Enzymes in the mouth and stomach unbind B12 from food proteins, allowing it to be absorbed and utilized (1)

In LPS-stimulated DCs, a recent study has found that activation of Sesn2 in the ferroptosis network can regulate the immunological function of DCs (74)

These findings suggested that Sirt1 may affect microglial activation through various signaling pathways