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Figures Abstract 1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity

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25, 38, 39 The combination of BSO (200 M) and L-PAM (25 M) achieved very strong synergism (CIN 0.1) in RPMI-8226 ( TP53 , KRAS and EGFR mutations) and U266 ( TP53 -mutation) cell lines, 38, 40 and strong synergism (CIN 0.10.3) was seen in MM.1S ( TP53 -wt and t(14;16)), KMS-12-PE (t(11;14) (q13;q32)) and EJM ( TP53 -mutation)

This could be due to several reasons

The future of metabolic medicine may involve multi-hormone therapies rather than single pathways