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(2019) NAcetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinsons Disease

2019;14(9):e0222135

DeFronzo, MD Professor of Medicine Chief of the Diabetes Division University of Texas Health Science Center at San Antonio Disclosures: DeFronzo reports serving on an advisory board for Aardvark, Alnylam, AstraZeneca, Boehringer Ingelheim, Corcept, Intarcia, Novo Nordisk and Renalytix

Competing interests D.G

However, individual results vary based on starting weight, dose, diet adherence, and metabolic factors

In detail, epigenetic modifications lead to mutations on enzymes involved in metabolic pathways (among which the best noted are SDH, FH, and IDH) which in turn cause the accumulation of oncometabolites (as mentioned before, succinate, fumarate, and 2-hydroxyglutarate) that stimulates alterations in DNA and histone modifications [28]