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The complexity of lipidated peptide impurity profiles, as the January 2026 Analytical Scientist review documented, requires orthogonal analytical methods capable of separating and characterising species that differ by a single amino acid residue or by the presence or absence of a single linker modification
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SalB exhibits the ability to upregulate the FGF19/FGFR4 pathway, which was disrupted by lipopolysaccharide (LPS) treatment, with the result that HSC activation and proliferation are inhibited (Tian et al., 2021)
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doi: 10.3389/fimmu.2024.1385006 Received 11 February 2024 Accepted 14 May 2024 Published 04 June 2024 Volume 15 - 2024 Edited by Roberto Paganelli, Institute for Advanced Biologic Therapies, Italy Reviewed by Wataru Fujii, Kyoto Prefectural University of Medicine, Japan Corinna Wehmeyer, University of Mnster, Germany Lia Pulsatelli, Rizzoli Orthopedic Institute (IRCCS), Italy Updates Copyright 2024 Damerau, Rosenow, Alkhoury, Buttgereit and Gaber
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