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AOD-9604 enhances one component of energy balance (fat oxidation from adipose stores) without creating the negative energy balance that results from appetite suppression or the metabolic rate increases seen with thermogenic compounds

When a subject met the inclusion criteria, measurements of heart rate, blood pressure, respiratory variation of pulse pressure, echocardiography, and arterial/venous blood gas levels were obtained at each step of the study: baseline (time 1), immediately after administration (time 2), 30 min after administration (time 3), 60 min after administration (time 4)

Mechanism: Increases collagen and proteoglycan production in cartilage

doi: 10.1002/cne.901790311

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For Hashimoto thyroiditis, the anti-inflammatory effects of GLP-1 therapy are particularly relevant