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Some patients benefit from low-dose anxiety support (magnesium glycinate, L-theanine) discussed with their healthcare provider

This increases cancer risk by two distinct mechanisms both through the promotion of chronic inflammation, and through inhibition of the acute inflammation that is important to halt tumorigenesis (anti-tumor immunity)

NICE Clinical Knowledge Summary guidance on erectile dysfunction recommends assessing for underlying conditions, particularly cardiovascular disease and diabetes complications

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Important considerations include: Tirzepatide is not indicated for type 1 diabetes or diabetic ketoacidosis and is not a substitute for insulin No dose adjustment is required in renal impairment, but patients should be monitored for dehydration risk, particularly with significant gastrointestinal side effects Caution is advised in patients with a history of pancreatitis Warnings and precautions apply for patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 Prescribing in primary care requires initiation at 2.5 mg once weekly for 4 weeks (a non-therapeutic starting dose to improve tolerability), then escalation to 5 mg weekly