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Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells

Epub ahead of print

New England Journal of Medicine 2013;368(2):14960

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An open-label placebo-controlled trial enrolled 77 people with elevated LDL cholesterol and triglycerides and randomized them into four groups: 1) placebo, 2) 10 mg or 20 mg daily of rosuvastatin, 3) bergamot polyphenols, and 4) bergamot polyphenols plus 10 mg rosuvastatin