Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
This brings up the question of, you know, why was there a similar level of A1C reduction, not something superior like we see with the weight reduction
This sustains results without continued dose increases
That gap between mazdutide and retatrutide is not trivial
There is also some data to suggest that GLP-1 may improve the gut microbiome to a pattern that is more favourable to weight loss
Several compounded options and supplements are hidden inside the patient portal