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Both approaches fail

The entire rationale collapses into a single word: timescale

It is important to note that organelle-containing erythroid lineage cells can undergo intrinsic [37] and extrinsic apoptosis [38], receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-dependent necroptosis [39], or iron-driven ferroptosis [40]

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The development of this ischemic penumbra is limited in time by a cascade of reactions in response to the initial ischemia followed by subsequent reperfusion