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In the placebo group, no significant effects were observed

Hippo signaling regulates YAP primarily through large tumor suppressor kinases 1 and 2 (LATS 1/2), which are activated through phosphorylation by mammalian sterile 20-like protein kinases 1/2 (MST1/2)

Additional file 2: Figure S4) than the WT group did, indicating impaired spatial learning ability in APP/PS1 transgenic mice

Youll notice initial results within a few weeks and significant weight loss over the course of the treatment

& Landfester, K

Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment