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In vitro studies showed that DHLA in addition to Co 2+ , Ni 2+ , Cd 2+ , Cu 2+ , Zn 2+ , Pb 2+ , and Hg 2+ also chelates Fe 3+ (its complex is more stable than that formed with Fe 2+ ), whereas ALA preferentially binds Mn 2+ , Cu 2+, Zn 2+ , and Pb 2+ but cannot chelate Fe 3+ [14,15]

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F.XiangC.et al (2007a)

In some instances, a combination of a therapeutic agent and a salt of the therapeutic agent is used to prepare pulsed release otic formulations or compositions using the procedures described herein

Charge separation propensity of the coenzyme B12tyrosine complex in adenosylcobalamin-dependent methylmalonylCoA mutase enzyme