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Interestingly, VCN-01, an oncolytic virus expressing hyaluronidase, showed encouraging clinical activity in PDAC, achieving an ORR of 50% in a phase I trial [440], implying that the delivery method for HA-degrading enzyme could make a difference in therapeutic outcomes

An MTHFR result does not determine whether folic acid, folinic acid, methylfolate, methyl-B12 or other methylation support is appropriate

First, it creates controlled micro-wounds that trigger wound-induced hair neogenesis

Can too much prenatal folate cause undermethylation

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T.CelestinoI.CoppoL.HolmgrenA.et al (2017)