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Two large trials from drugmaker Novo Nordisk found that an oral version of semaglutide, the active ingredient in Ozempic and Wegovy, failed to delay Alzheimers disease progression in more than 3,800 adults with mild cognitive impairment or early dementia

[DOI] [PubMed] 32.Akter T, Zahan MS, Nawal N, Rahman MH, Tanjum TN, Arafat KI, Moni A, Islam MN, Uddin MJ

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Oral semaglutide versus injectable glucagon-like peptide-1 receptor agonists: a cost of control analysis

(2023) demonstrated that both RIPK1 and IL-8 were elevated in the serum of ALS patients, with RIPK1 concentrations correlating with symptom severity