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Because amylin receptors are obligate heterodimers of the calcitonin receptor with RAMP1, RAMP2 or RAMP3, the system is a standard model for studying how accessory proteins reshape the ligand binding pocket of a class B1 GPCR, and cagrilintide is used to probe that question alongside selective agonists

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Based on the above research findings, we hypothesize that beneficial Clostridium and its metabolites regulate adaptive immunity and induce immune tolerance in RA, thereby synergistically alleviating joint immune damage

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