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Optimizing prepregnancy cardiovascular health to improve outcomes in pregnant and postpartum individuals and offspring: a scientific statement from the American Heart Association

In this context, the antitumor activity reported for incretin-based polyagonists should not be interpreted as evidence for GCGR agonism alone, but rather as an indication that coordinated multi-receptor targeting may induce favorable systemic metabolic remodeling (62,63)

doi: 10.1016/j.cmet.2018.03.001 97 HolscherC

For researchers prioritizing muscle preservation, a moderate dose of 4 to 8 mg combined with adequate protein intake (1.0 to 1.2 grams per kilogram of body weight) and resistance training appears to optimize the fat-to-lean mass loss ratio