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A disrupted NAD + /NADH balance may contribute to the development of many diseases, including cardiovascular and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, metabolic disorders such as type 2 diabetes, and inflammatory skin conditions such as acne and psoriasis (135137)

The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

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Proposed exploratory objectives including functional and phenotypic characterization of SARS-CoV-2-specific immune cells, cytokine synthesis, cellular proliferation, and mucosal antibody concentrations