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However, these same pathways might also intensify craving during initial withdrawal phases, potentially accelerating relapse

Conversely, oxidative stress is attributed to unbridled production of ROS, surpassing the amount of antioxidant defenses and aggravating damage to cells, proteins, lipids and DNA, 18 a process which is also indicated by Fig

Folic acid supports the trans-methylation pathway, which metabolizes homocysteine into cysteine

These injuries often lead to severe and long-lasting impairments, and the ability to mitigate their adverse consequences is crucial

doi: 10.1038/nri3738 137 BrownEMSadaranganiMFinlayBB

Delgado-Esteban M, Almeida A, Bolanos JP