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However, safety concerns with hydroquinone led to withdrawal of the Kligman formula in several countries [6, 27, 74, 77, 90]

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Molecular docking and molecular dynamics simulations have revealed that N-terminal residues form stable estrogen complexes via hydrogen bonds and hydrophobic interactions, enhancing cellular responses [17]

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Peroxidases, including glutathione peroxidase 4 (GPX4), metabolize hydroperoxy-phospholipids to hydroxy derivatives to prevent ferroptotic death, but consume reduced glutathione (GSH)

Thyroid cancer cases remained rare and did not appear significantly higher compared with placebo groups