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In addition to L cells, preproglucagon neurons in the brain stem produce GLP-1, but how inflammation affects these neurons, and the role of brain-derived GLP-1 in local or systemic inflammation, are unknown

A., Hassan, N

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The data offer early evidence that the injection can be administered less frequently than existing drugs without sacrificing efficacy, which could be a major boost for Pfizer after it faced several setbacks in developing obesity drugs

Pre-clinical data suggests that blockade of latent TGF production by CRB-601 can lead to changes in immune cell infiltration in the tumor microenvironment, potentially enhancing the benefit of PD-1 blockade