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Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats

This window is necessary because food, stomach pH, and other substances interfere with absorption

So, yes reduction of body fat mass while maintaining or building lean body mass is possible, which involves resistance training, an individualized healthy rate of fat loss, macronutrient / calorie modulation, high protein, supplements / nutraceuticals, plenty of low carb vegetables, etc

J Diabetes Metab Disord 24 , 160 (2025)

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Metabolic pathways that become active due to high blood sugar levels: an increase in the flow of the polyol pathway Conversion of glucose to sorbitol osmotic stress, reduction of NADPH increased oxidative stress damaging nerves (77)