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An exemplary case of MRTX849, a covalent inhibitor targeting KRAS G12C mutant, benefited from a lower reactivity warhead with an additional fluorine at the acrylamide -carbon position, thus achieving better metabolic stability [113]

Peptydy s zwizkami chemicznymi zbudowanymi, tak samo jak biaka, z aminokwasw, ktre poczone s ze sob wizaniem peptydowym

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IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

Measurement of cell viability, apoptosis and glutathione reductase activity HepG2 cells (purchased from Shanghai Institutes for Biological Sciences, Shanghai, China) were cultured in type B medium containing 12.76 nmol/L riboflavin before being transferred into the media with different riboflavin concentrations (0.76, 3.76, 12.76, 24.76, 48.76 nmol/L)

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