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Or do you need supplements, too

GHK-Cu (Copper Tripeptide-1) is a naturally occurring peptide found in the body that supports skin repair and renewal processes, including collagen production and overall skin quality

Zinc essentiality, toxicity, and its bacterial bioremediation: A comprehensive insight

In a landmark human trial comparing topical GHK-Cu to vitamin C and retinoic acid (tretinoin), GHK-Cu produced measurable collagen increases in 70% of study volunteers outperforming both comparator treatments (Abdulghani et al., 1998)

A copper peptide cream would work well as part of the "sandwich method." Tretinoin is known to be extremely drying to the skin because it promotes fast cell turnover, so sandwiching a copper peptide cream can help you lock in moisture

This has been done for some of the stronger genetic PD risk factors (e.g