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Injection site reactions (erythema, pruritus, swelling) occur in 1.4-2.4% of patients using subcutaneous formulations and are well-documented, localized effects

Glucocorticoids inhibit neutrophil apoptosis and demargination

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Some incretins (like GLP-1) can inhibit release of glucagon

The clinical data from PIONEER-4 and SUSTAIN-7 show comparable efficacy across semaglutide formulations, so the decision often comes down to cost, coverage, and patient preference for oral versus injectable administration