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BPC-157 has been shown to upregulate epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and nerve growth factor (NGF) expression in multiple rodent tissue models

Temperature excursions above 8C cause protein denaturation

The longer-term results and less reinjection and/or surgery rate of PRP makes it more attractive as an injection treatment option versus corticosteroids injection

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control