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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

& Strutton, G

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Side effects are typically mild and short-lived, with dosing carefully managed to ensure safety and optimal results

The excess glutamate impairs xc- system activity, leading to heightened neuronal excitability, excessive activation of extrasynaptic N-methyl-D-aspartate (NMDA) receptors, and, in severe cases, excitotoxicity [83, 84]