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The Kidney Disease Improving Global Outcomes 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends adults with CKD and either an eGFR 20 mL/min/1.73 m 2 or higher plus UACR of 200 mg/g or higher, or those with heart failure, receive SGLT2 inhibitor therapy
Cells 11 (19), 3021 (2022)
(2) diagnosis with multiple diabetic complications (E11.7 by the ICD-10)
In addition, the FDA approved oral semaglutide in 2019, becoming the first oral dosage form of a GLP-1 receptor agonist
Abbreviations AIF: apoptosis-inducing factor ALF: acute liver failure ALT: alanine aminotransferase APACHE II: acute physiology and chronic health evaluation II APAP: acetaminophen AST: aspartate transaminase ATP: adenosine triphosphate DAMP: damage-associated molecular pattern DILI: drug-induced liver injury EndoG: endonuclease G FDA: Food and Drug Administration GDCA: glycodeoxycolic acid GDH: glutamate dehydrogenase GSH: glutathione HMGB1: high mobility group B1 HPLC: high-pressure liquid chromatography INR: international normalized ratio IV: intravenous JNK: c-Jun-N-terminal kinase KCH: Kings College Hospital KIM 1: kidney injury molecule 1 MELD: model for end-stage liver disease miRNA: microRNA mtDNA: mitochondrial DNA NAC: N -acetyl cysteine NAPQI: N -acetyl-para-benzo-quinone imine nDNA: nuclear DNA NK: natural killer NKT: natural killer T cells PO: oral SFN: sulforaphane SOFA: sequential organ failure assessment SULT: sulfotransferase UGT: UDP-glucoronosyl transferase Declarations Conflict of interest None Authors contributions Contributed to the manuscript by drafting the document, formatting the figures and tables, obtaining permission for use of previously published figures, and performing final editing of the content (EY), contributed to the manuscript by writing content and formatting the tables in the manuscript (AB), contributed to the manuscript by drafting sections of the document (MC), contributed to the manuscript by providing editing comments (MK), contributed to the manuscript by providing critical revision and administration during the manuscript writing (NP).
These are three of the most debilitating and treatment-resistant symptoms in endometriosis
