Before a drug candidate can be administered to humans, it must be supported by years of scientific research, non-clinical investigation and quality assessment aimed at understanding its mechanism of action, safety profile and potential therapeutic value
Despite improvements in macroscopic circulation, epinephrine may contribute to a microvascular paradox , whereby cerebral microcirculatory blood flow is reduced despite increased systemic perfusion
SGLT2 inhibition reduces glucose reabsorption at the level of the proximal renal tubule, promotes urinary glucose excretion independent of insulin action, and causes a negative caloric balance ( Figure 1 )
Tirzepatide vs Semaglutide: Clinical Trial Results Compared Tirzepatide vs Semaglutide Head-to-head comparison of clinical trial results between these two compounds
The glucagon component adds thermogenic and lipolytic signaling pathways not present in GLP-1-only or dual GIP/GLP-1 compounds
Extracellular glutathione peroxidase GPx3 and its role in cancer
