F.et al (2017)
American Diabetes Association (2021) 9
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Thus, the most accurate interpretation is not safe, but rather no stable teratogenic signal identified to date, with evidence still insufficient for a safety conclusion (132). In clinical counseling, this distinction matters: inadvertent early exposure should generally prompt individualized risk communication and obstetric follow-up, not automatic reassurance and not automatic inference of major harm
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It also supports gene signaling that promotes new collagen and elastin