Additionally, melatonin can exert its effects by acting through receptor-independent pathways [6] , which involve the direct interaction of melatonin and other molecules, mainly related to its antioxidant and radical scavenging action [22,26]
Second, the mechanistic analysis was not performed to explain why removing senescent cells did not result in more cartilage formation
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3.2 Curcumin: potential risks and challenges Despite numerous studies highlighting the potential benefits of CUR, certain adverse effects and toxicities have been reported, particularly at high doses or with prolonged use
Loren Pickart estimated toxic action starting at approximately 22,500 mg (300-fold above effective doses), though some users report mild blood pressure effects even at normal doses
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