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There was no increased risk for hypoglycemia in the lixisenatide group

Why do people regain weight after stopping GLP-1s

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Lancet Neurol (2015) 14(9):94555

Some studies have demonstrated an increased risk of depression and anxiety in individuals taking GLP-1s, and, anecdotally, some patients report experiencing emotional numbing when taking GLP-1 medications." And, she warned, the drugs could exacerbate disordered eating for some people

Depot effect at the injection site : The fatty acid moiety promotes self-association and interaction with subcutaneous tissue components at the injection site, creating a slow-release depot that contributes to sustained absorption after subcutaneous administration