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Weight of evidence: Overall evidence is ModerateHigh in FR- Ab + children

This is not a peripheral effect

It was the first treatment FDA Market Cleared for overall body circumference reduction

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It is also used in glutamate-cysteine ligase regulation and Nrf2/ARE pathway work, where glutathione acts as the feedback inhibitor of its own synthesis (Lu, Biochimica et Biophysica Acta, 2013)