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Antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1) and its ligand [programmed death-ligand 1 (PD-L1)] are the most consolidated options (9)

Nevertheless, the relatively short duration of follow-up remains a major limitation because the time required for PDAC to emerge from a normal cell is estimated to be greater than 10 years 31

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