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6 The homocysteine-methionine conversion is also essential for the generation of S-adeno-sylmethionine, a methyl donor involved in the methylation of DNA and the synthesis of lipids, proteins, and neurotransmitters in the nervous system
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Fat-soluble vitamins, such as Vitamin K, D, E, and A, are stored in the liver and fat tissues
However, long-term human studies specifically examining extended use remain limited
Vitamin B12: Targeted nutritional support Long-term B12 supplementation can provide: Sustained support for nervous system health Ongoing prevention of megaloblastic anemia Potential cognitive benefits, particularly in older adults Support for bone health and reduced risk of osteoporosis For individuals with chronic B12 deficiency or absorption issues, long-term supplementation may be necessary to maintain optimal health
However, juvenile or adult onset manifestations characterized mainly by ataxia, dementia, and psychosis have been described [2, 4]
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