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Strategic stacking, combining peptides with complementary mechanisms, allows researchers to address multiple contributing factors simultaneously

With the matched group on semaglutide, 28 reported gastroparesis.[ref][ref] Diabetic retinopathy: Two clinical trials in people with diabetes linked GLP-1 RA drugs to an increased risk of diabetic retinopathy, while other studies show that the drugs were not associated with the eye disease

PMID 16677080

Clin Gastroenterol Hepatol 20(12):2809-2817.e28

The GIP receptor agonism complements GLP-1 receptor activation by enhancing glucose-dependent insulin secretion, thereby improving glycemic control and weight loss more effectively than GLP-1RAs alone