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Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths
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Based on current evidence, it is too early to conclude that GLP-1 receptor agonists are effective treatments for addiction
This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover
15% Hunger GLP-1 therapy in humans reduces food intake Appetite and hunger and promotes fullness and satiety with the ultimate result of promoting weight loss
Many patients may, therefore, be at risk of adverse effects and uncertain long-term outcomes
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